Faster patching is needed: Barr is concerned about the flaw in finding N-day abuse. “While it’s positive that Cisco is transparent in disclosure and swift in releasing patches, the reality is that patching these types of vulnerabilities, especially in large, distributed enterprise environments, is not instantaneous,” he said. “Restart requirements and dependencies on high-availability setups often delay full remediation.”He added that the speed and simplicity of modern exploit development, especially through AI, should be a concern.Jason Soroko, senior fellow at Sectigo, is more worried about the blast radius of a potential exploit. “ISE sits at the very edge of trust for many campus networks, and a breach can rewrite access policies, move endpoints between VLANs, and open pivots into every segment,” he said. “The vulnerable API is often reachable from broad internal address ranges, sometimes even guest Wi-Fi, and ISE patching requires disruptive maintenance windows.”Active targeting feels likely because the flaws (CVE-2025-20281) already attracted public proof-of-concept exploits and scan traffic within days, Soroko added.For additional protection, Barr recommends using specialized API security solutions that can detect and block anomalous API activity in real time, provide endpoint-risk scoring, and stop automated scanning and payload delivery.Cisco has had a busy month, weathering a downpour of max-severity bugs. Earlier this month, the company patched another root-access issue in its communications gear, though that one was self-inflicted, with DevOps quietly stashing hardcoded credentials for internal use.
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